4DHeart - 4D analysis of heart development and regeneration using advanced light microscopy
4DHeart is a Marie Skłodowska-Curie Innovative Training Network (ITN) funded by the European Commission Horizon2020 programme (grant agreement: 722427) focusing on understanding the development, function and disease of the cardiovascular system. The project will run for 4 years from January 2017. As an European industrial training network the project establishes academia-industry partnerships by bringing together experts from companies and universities from the fields of biology, microscopy, optics and bio-computing.
- Train experts on cardiovascular research through the use of live imaging.
- Intersectoral training in industrial and academic environments.
- Use imaging tools such as light sheet microscopy, high content screening and advanced image processing to analyse cardiovascular development and disease.
4DHeart will recruit 6 Early stage researchers (ESR) that will develop their own technology to solve a biological problem at the frontier of knowledge. ESRs will receive multidisciplinary (cardiovascular development, physics, bio-computing) as well as inter sectorial (academic research, SMEs, large companies) training and will achieve unique skills on microscopy and image analysis allowing them to interrogate questions on cardiac development and regeneration.
Within 4DHeart, DITABIS and the University of Bern, Switzerland (Prof. Dr. Nadia Mercader) will develop and establish a zebrafish high content screening assay to score larval cardiac phenotypes and study the effect of small molecules on epicardium formation. This will involve the development of sample preparation and embryo handling protocols, image acquisition routines for smart screening of embryonic, automated image data processing pipelines as well as the conduction of a small molecule screen and the validation of selected compounds in secondary assays.
Link to project homepage: www.4dheart.eu